Recent progress in the development of selective S1P1 receptor agonists for the treatment of inflammatory and autoimmune disorders
Author:
Publisher
Informa Healthcare
Subject
Drug Discovery,Pharmacology,General Medicine
Link
http://www.tandfonline.com/doi/pdf/10.1517/13543776.18.10.1141
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1. Sphingosine 1‐phosphate released from platelets during clotting accounts for the potent endothelial cell chemotactic activity of blood serum and provides a novel link between hemostasis and angiogenesis
2. The Balance between Sphingosine and Sphingosine-1-Phosphate Is Decisive for Mast Cell Activation after Fc∈ Receptor I Triggering
3. Erythrocytes store and release sphingosine 1‐phosphate in blood
4. Extracellular Export of Sphingosine Kinase-1 Enzyme
5. Promotion of Lymphocyte Egress into Blood and Lymph by Distinct Sources of Sphingosine-1-Phosphate
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