Label-free kinetic binding data as a decisive element in drug discovery
Author:
Publisher
Informa Healthcare
Subject
Drug Discovery
Link
http://www.tandfonline.com/doi/pdf/10.1517/17460441.1.5.439
Reference41 articles.
1. Evidence that Structural Rearrangements and/or Flexibility during TCR Binding Can Contribute to T Cell Activation
2. Biochemical mechanisms of drug action: what does it take for success?
3. The Importance of Enzyme Inhibition Kinetics for the Effect of Thrombin Inhibitors in a Rat Model of Arterial Thrombosis
4. Relationships between Structure and Interaction Kinetics for HIV-1 Protease Inhibitors
5. A new strategy for improved secondary screening and lead optimization using high-resolution SPR characterization of compound-target interactions
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