Haplotype analysis in population genetics and association studies-Reference-Cited by-同舟云学术

Haplotype analysis in population genetics and association studies

Published:2003-03-01 Issue:2 Volume:4 Page:171-178
ISSN:1462-2416
Container-title:Pharmacogenomics
language:en
Short-container-title:Pharmacogenomics

Author:

Zhao Hongyu¹,Pfeiffer Ruth²,Gail Mitchell H²

Affiliation:

1. Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520, USABiostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA

2. Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA

Abstract

Several studies of haplotype structures in the human genome in various populations have been published recently. Such knowledge may provide valuable information on human evolutionary history and lead to the development of more efficient strategies to identify genetic variants that increase susceptibility to human diseases. In this review, we summarize the current understanding of haplotype structure, diversity, and distribution in the human genome, with a focus on statistical issues in using haplotypes for studies of population genetics and evolutionary history, as well as to identify genetic variants underlying complex human traits.

Publisher

Future Medicine Ltd

Subject

Pharmacology,Genetics,Molecular Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.1517/phgs.4.2.171.22636

Reference59 articles.

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5. Linkage disequilibrium in the human genome

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