Pharmacogenomic strategies against resistance development in microbial infections

Author:

Ziebuhr Wilma1,Xiao Ke2,Coulibaly Boubacar3,Schwarz Roland4,Dandekar Thomas5

Affiliation:

1. Institut fur Molekulare Infektions biologie, Rontgenring 11, 97070 Wurzburg, Germany

2. Biochemiezentrum, Haus 3, Im Neuenheimer Feld 504, 69120 Universitat Heidelberg, Germany

3. Centre de Recherche en Sante de Nouna, BP2, Nouna, Burkina-Faso

4. Lehrstuhl fur Bioinformatik, Biozentrum, Am Hubland, 97074 Universitat Wurzburg, Germany

5. Lehrstuhl fur Bioinformatik, Biozentrum, Am Hubland, 97074 Universitat Wurzburg, Germany, European Molecular Biology Laboratory, Postfach 102209, 69120 Heidelberg, Germany. dandekar@biozentrum.uni-wuerzburg.de

Abstract

There are several promising new strategies against resistance development in microbial infections. This paper discusses typical experimental and bioinformatical strategies to study the impact of infectious challenges on host–pathogen interaction, followed by several novel approaches and sources for new pharmaceutical strategies against resistance development. Genomics reveals promising new targets by providing a better understanding of cellular pathways, through the identification of new pathways, and by identifying new intervention areas, such as phospholipids, glycolipids, innate immunity, and antibiotic peptides. Additional antibiotic resources come from new genomes, including marine organisms, lytic phages and probiotic strategies. A system perspective regards all interactions between the host, pathogen and environment to develop new pharmacogenomic strategies against resistance development.

Publisher

Future Medicine Ltd

Subject

Pharmacology,Genetics,Molecular Medicine

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