Online genomics facilities in the new millennium

Author:

Frishman Dmitrij1,Kaps Andreas2,Mewes Hans-Werner3

Affiliation:

1. Institute for Bioinformatics, GSF - National Research Center for Environment and Heatlh, Ingolstädter Landstraße 1, 85764 Neueherberg, Germany

2. Biomax Informatics AG, Lochhamer Straße 11, 82152 Martinsried, Germany

3. Institute for Bioinformatics, GSF - National Research Center for Environment and Heatlh, Ingolstädter Landstraße 1, 85764 Neueherberg, GermanyTechnical University of Munich,Wissenschaftszentrm Weihenstephan, D-85350 Freising-Weihenstephan

Abstract

The review begins by providing a brief typology of biological databases on the Internet, illustrated by examples of the most influential resources of each kind. We then take an insider look at one typical on-line genomic resource – the yeast genome database hosted at the Munich Information Center for Protein Sequences (MIPS) – and explain how and why it has evolved from a basic sequence repository to a multidomain knowledge base. The role of community efforts in curating and annotating genome data is discussed. The crucial role of data integration and interoperability in developing next-generation genomic facilities is underscored.

Publisher

Future Medicine Ltd

Subject

Pharmacology,Genetics,Molecular Medicine

Reference33 articles.

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