Association of genetic variations in HLA-B region with hypersensitivity to abacavir in some, but not all, populations

Author:

Hughes Arlene R,Mosteller Michael,Bansal Aruna T,Davies Kirstie,Haneline Stephen A,Lai Eric H,Nangle Keith,Scott Trevor,Spreen William R,Warren Liling L,Roses Allen D,on behalf of the CNA30027 and CNA30

Publisher

Future Medicine Ltd

Subject

Pharmacology,Genetics,Molecular Medicine

Reference13 articles.

1. Cutrell A, Hernandez JE, Edwards M etal: Clinical risk factors for hypersensitivity reactions to abacavir: retrospective analysis of over 8,000 subjects receiving abacavir in 34 clinical trials. 43rd Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago, IL, USA (2003) (Abstract H-2013).

2. Genetic variations in HLA-B region and hypersensitivity reactions to abacavir

3. Association between presence of HLA-B*5701, HLA-DR7 , and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir

4. Pirmohamed M: P450 polymorphisms and adverse drug reactions. British Toxicology Society Meeting, Manchester, UK (2002) (Abstract).

5. Hypersensitivity reactions during therapy with the nucleoside reverse transcriptase inhibitor abacavir

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