Cytochrome P450 1B1: a novel anticancer therapeutic target-Reference-Cited by-同舟云学术

Cytochrome P450 1B1: a novel anticancer therapeutic target

Published:2005-04 Issue:2 Volume:1 Page:259-263
ISSN:1479-6694
Container-title:Future Oncology
language:en
Short-container-title:Future Oncology

Author:

McFadyen Morag CE¹,Murray Graeme I²

Affiliation:

1. Robert Gordon University, School of Pharmacy, Schoolhill, Aberdeen, AB10 1FR, UK.

2. University of Aberdeen, Department of Pathology, Aberdeen, UK

Abstract

Cytochrome P450 (CYP)1B1 is overexpressed in tumor cells and is also recognized as a biomarker of the tumor phenotype. This review highlights the tremendous potential of this enzyme as a novel cancer therapeutic target. The range of therapeutic strategies including immunotherapeutics, CYP1B1-activated prodrugs and CYP1B1 inhibitors, that are currently being developed to exploit the presence and activity of CYP1B1 in tumor cells is outlined. The therapeutic strategy, which is at the most advanced stage of development, is a CYP1B1-based vaccine which has already successfully completed a Phase I clinical trial.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Oncology,General Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.1517/14796694.1.2.259

Reference34 articles.

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