VARIATIONS IN THE CLINICAL COURSE OF CEREBRAL VENOUS THROMBOSIS

Abstract

The goal of the paper is to study risk factors and variations in the clinical course of cerebral venous thrombosis (CVT). Materials and Methods. We examined 50 patients with CVT aged 25–77 (mean age 52.5±14): 15 men (30.0 %) aged 46–75 (mean age 54±12) and 35 women (75.0 %) aged 25–77 (mean age 53.5±14). A complete clinical and neurological examination was carried out, including an assessment of complaints, medical history, neurological examinations, which distinguish variations in the clinical course. The most obvious risk factors for each variation in clinical course have been identified. Results. We have identified the following variations in the CVT clinical course: acute manifestation in the form of generalized epileptic seizures and/or impaired consciousness – 17 (34.0 %) cases; isolated headache – 10 (20.0 %) cases; focal neurological symptoms – 6 (12.0 %) cases; gradual onset – 17 (34.0 %) cases. For acute manifestation in the form of epileptic seizures and/or impaired consciousness, the most typical risk factors were arterial hypertension – 9 (52.9 %) cases, obesity – 10 (58.8 %) cases, insufficient physical activity – 9 (52.9 %) cases. For isolated headache and gradual onset option, cerebrovascular insufficiency was a statistically significant risk factor (p<0.05). The most significant risk factors for patients with focal neurological symptoms were arterial hypertension and atherosclerosis (p<0.05). There were no statistically significant differences in the cerebral thrombosis localization based on the clinical course. Conclusion. Identification of risk factors and variations in the CVT clinical course in combination with neuroimaging methods helps to improve CVT diagnosis.