A Validated Quantitative 1H Nuclear Magnetic Resonance (1H-qNMR) Method for Quantification of a Novel Anti-Coagulant Drug (Betrixaban Maleate) with Assessing Its Stability by Application to Degradation Study-Reference-Cited by-同舟云学术

A Validated Quantitative 1H Nuclear Magnetic Resonance (1H-qNMR) Method for Quantification of a Novel Anti-Coagulant Drug (Betrixaban Maleate) with Assessing Its Stability by Application to Degradation Study

Published:2020-11-01 Issue:6 Volume:10 Page:768-783
ISSN:2229-7928
Container-title:Analytical Chemistry Letters
language:en
Short-container-title:Analytical Chemistry Letters

Author:

El-Masry Amal A.¹,Zeid Abdallah M.²,El-Wasseef Dalia R.¹³,Eid Manal²,Shehata Ihsan A.¹

Affiliation:

1. Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, 35516 Mansoura, Egypt

2. Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Mansoura University, 35516 Mansoura, Egypt

3. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Delta University for Science and Technology, 35712, Gamasa, Egypt

Publisher

Informa UK Limited

Link

https://www.tandfonline.com/doi/pdf/10.1080/22297928.2021.1875873

Reference23 articles.

1. Diagnosis and treatment of deep-vein thrombosis

2. Discovery of betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide, a highly potent, selective, and orally efficacious factor Xa inhibitor

3. Diehl, B., Chapter 1 - Principles in NMR Spectroscopy: Holzgrabe, U., Wawer, I., Diehl, B., editors (2008). NMR Spectroscopy in Pharmaceutical Analysis. Amsterdam: Elsevier. 1–41.

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