Vaccinia-based oncolytic immunotherapy Pexastimogene Devacirepvec in patients with advanced hepatocellular carcinoma after sorafenib failure: a randomized multicenter Phase IIb trial (TRAVERSE)

Author:

Moehler M.1,Heo J.2ORCID,Lee H.C.3,Tak W.Y.4ORCID,Chao Y.5,Paik S.W.6,Yim H.J.7ORCID,Byun K.S.8,Baron A.9,Ungerechts G.10,Jonker D.11,Ruo L.12,Cho M.13,Kaubisch A.14,Wege H.15,Merle P.16,Ebert O.17,Habersetzer F.18,Blanc J.F.19,Rosmorduc Olivier20,Lencioni R.21,Patt R.22,Leen A.M.23,Foerster F.1ORCID,Homerin M.24,Stojkowitz N.25,Lusky M.26,Limacher J.M.27,Hennequi M.28,Gaspar N.29,McFadden B.30,De Silva N.31,Shen D.31,Pelusio A.31,Kirn D.H.32,Breitbach C.J.31,Burke J.M.31

Affiliation:

1. First Department of Medicine, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany

2. College of Medicine, Pusan National University and Medical Research Institute, Pusan National University Hospital, Busan, Republic of Korea

3. Asan Medical Center, University of Ulsan College of Medicine, Ulsan, Republic ofKorea

4. School of Medicine, Kyungpook National University Medical Center, Daegu, Republic of Korea

5. Department of Oncology, Taipei Veterans General Hospital, Taipei, Taiwan

6. Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea

7. Department of Internal Medicine, Korea University Ansan Hospital, Ansan-si, Republic of Korea

8. Department of Internal Medicine, Korea UniversityCollege of Medicine, Seoul, Republic of Korea

9. Department of Medicine, California Pacific Medical Center, San Francisco, CA, USA

10. Department of Medical Oncology, National Center for Tumor Diseases (NCT) and Heidelberg University Hospital, Heidelberg, Germany

11. The Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Canada

12. Department of Surgery, Juravinski Hospital and Cancer Centre, McMaster University, Hamilton, Canada

13. Department of Internal Medicine, Pusan National University Yangsan Hospital, Busan, Republic of Korea

14. Department of Medicine, Montefiore Medical Center, New York, NY, USA

15. Department of Medicine, Gastroenterology and Hepatology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

16. Hepatology Unit, Croix-Rousse Hospital, Lyon, France

17. Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University, Munich, Germany

18. Pôle Hépato-Digestif, Hôpitaux Universitaires de Strasbourg, INSERM 1110, IHU de Strasbourg and Université de Strasbourg, Strasbourg, France

19. Hepato-Gastroenterology and Digestive Oncology Department, CHU Bordeaux, Bordeaux, France

20. Sorbonne Université, AP-HP, Hôpital Paul Brousse, Villejuif, France

21. Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA

22. Rad-MD, New York, NY, USA

23. Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA

24. Medical Affairs, Transgene S.A., Illkirch-Graffenstaden, France

25. Clinical Operations, Transgene S.A., 400 Bd Gonthier d’Andernach, Parc d’Innovation, 67405 Illkirch-Graffenstaden, France

26. Program Management, Transgene S.A., 400 Bd Gonthier d’Andernach, Parc d’Innovation, 67405 Illkirch-Graffenstaden, France

27. Medical Affairs, Transgene S.A., 400 Bd Gonthier d’Andernach, Parc d’Innovation, 67405 Illkirch-Graffenstaden, France

28. Biostatistics, Transgene S.A., 400 Bd Gonthier d’Andernach, Parc d’Innovation, 67405 Illkirch-Graffenstaden, France

29. Clinical Assays, SillaJen Inc., San Francisco, CA, USA

30. Analytical Development and Quality Control, SillaJen Inc., San Francisco, CA, USA

31. Clinical, SillaJen Inc., San Francisco, CA, USA

32. SillaJen Inc., San Francisco, CA, USA

Funder

Transgene S.A.

Sillajen Biotherapeutics

Publisher

Informa UK Limited

Subject

Oncology,Immunology,Immunology and Allergy

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