Tumor mutational burden is a determinant of immune-mediated survival in breast cancer

Author:

Thomas Alexandra12,Routh Eric D.3,Pullikuth Ashok3,Jin Guangxu23,Su Jing4,Chou Jeff W.25,Hoadley Katherine A.67,Print Cristin8ORCID,Knowlton Nick8,Black Michael A.9ORCID,Demaria Sandra10,Wang Ena11,Bedognetti Davide11ORCID,Jones Wendell D.12ORCID,Mehta Gaurav A.13,Gatza Michael L.13ORCID,Perou Charles M.67,Page David B.14,Triozzi Pierre12ORCID,Miller Lance D.23ORCID

Affiliation:

1. Section of Hematology and Oncology, Department of Internal Medicine, Wake Forest Baptist Medical Center, Winston-Salem, NC, USA

2. Wake Forest Comprehensive Cancer Center, Winston-Salem, NC, USA

3. Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC, USA

4. Division of Radiologic Sciences and Center for Bioinformatics and Systems Biology, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC, USA

5. Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA

6. Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

7. Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

8. Department of Molecular Medicine and Pathology and Maurice Wilkins Institute, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand

9. Department of Biochemistry, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand

10. Department of Radiation Oncology and Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY, USA

11. Department of Tumor Biology, Immunology and Therapy, Division of Translational Medicine, Sidra Medical and Research Center, Doha, Qatar

12. EA Genomics, Division of Q Solutions, Morrisville, NC

13. Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA

14. Department of Medicine, Providence Cancer Center, Earle A. Chiles Research Institute, Portland, OR, USA

Funder

American Cancer Society

HHS | NIH | National Cancer Institute

Publisher

Informa UK Limited

Subject

Oncology,Immunology,Immunology and Allergy

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