A novel nanobody-based target module for retargeting of T lymphocytes to EGFR-expressing cancer cells via the modular UniCAR platform

Author:

Albert Susann1,Arndt Claudia2,Feldmann Anja2,Bergmann Ralf2,Bachmann Dominik1,Koristka Stefanie2,Ludwig Florian1,Ziller-Walter Pauline1,Kegler Alexandra2,Gärtner Sebastian2,Schmitz Marc3,Ehninger Armin4,Cartellieri Marc5,Ehninger Gerhard678,Pietzsch Hans-Jürgen2,Pietzsch Jens29,Steinbach Jörg2789,Bachmann Michael1278

Affiliation:

1. Tumor Immunology, University Cancer Center (UCC), ‘Carl Gustav Carus,’ TU Dresden, Dresden, Germany

2. Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Institute of Radiopharmaceutical Cancer Research, Dresden, Germany

3. Institute of Immunology, ‘Carl Gustav Carus’, TU Dresden, Dresden, Germany

4. GEMoaB Monoclonals GmbH, Dresden, Germany

5. Cellex Patient Treatment GmbH, Dresden, Germany

6. Medical Clinic and Policlinic I, University Hospital ‘Carl Gustav Carus’, TU Dresden, Dresden, Germany

7. German Cancer Consortium (DKTK), partner site Dresden, Germany, and German Cancer Research Center (DKFZ), Heidelberg, Germany

8. National Center for Tumor Diseases (NCT), ‘Carl Gustav Carus,’ TU Dresden, Dresden, Germany

9. Department of Chemistry and Food Chemistry, School of Science, TU Dresden, Dresden, Germany

Publisher

Informa UK Limited

Subject

Oncology,Immunology,Immunology and Allergy

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