A gene expression signature associated with B cells predicts benefit from immune checkpoint blockade in lung adenocarcinoma

Author:

Budczies Jan12,Kirchner Martina1,Kluck Klaus12,Kazdal Daniel13,Glade Julia1,Allgäuer Michael1,Kriegsmann Mark13,Heußel Claus-Peter345,Herth Felix J.36,Winter Hauke37,Meister Michael38,Muley Thomas38,Fröhling Stefan29,Peters Solange10,Seliger Barbara11ORCID,Schirmacher Peter12,Thomas Michael712,Christopoulos Petros712,Stenzinger Albrecht13

Affiliation:

1. Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany

2. German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany

3. Translational Lung Research Center Heidelberg (TLRC-H), Member of the German Center for Lung Research (DZL), Heidelberg, Germany

4. Department of Diagnostic and Interventional Radiology with Nuclear Medicine, Thoraxklinik at Heidelberg University Hospital, Heidelberg, Germany

5. Department of Diagnostic and Interventional Radiology, Heidelberg University Hospital, Heidelberg, Germany

6. Department of Pneumology, Thoraxklinik at Heidelberg University Hospital, Heidelberg, Germany

7. Department of Thoracic Surgery, Thoraxklinik at Heidelberg University Hospital, Heidelberg, Germany

8. Translational Research Unit, Thoraxklinik at Heidelberg University Hospital, Heidelberg, Germany

9. Department of Translational Oncology, National Center for Tumor Diseases (NCT), Heidelberg, Germany

10. Department of Oncology, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne University, Lausanne, Switzerland

11. Institute for Medical Immunology, Martin Luther University Halle-Wittenberg, Halle, Germany

12. Department of Thoracic Oncology, Thoraxklinik and National Center for Tumor Diseases at Heidelberg University Hospital, Heidelberg, Germany

Funder

the German Center for Lung Research

German Cancer Consortium

Publisher

Informa UK Limited

Subject

Oncology,Immunology,Immunology and Allergy

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