Staphylococcus aureus alpha-toxin inhibits CD8+ T cell-mediated killing of cancer cells in cutaneous T-cell lymphoma

Author:

Blümel Edda1ORCID,Munir Ahmad Shamaila2ORCID,Nastasi Claudia1ORCID,Willerslev-Olsen Andreas1ORCID,Gluud Maria1ORCID,Fredholm Simon1ORCID,Hu Tengpeng1ORCID,Surewaard Bas G. J.3ORCID,Lindahl Lise M.4ORCID,Fogh Hanne5,Koralov Sergei B.6ORCID,Rahbek Gjerdrum Lise Mette7,Clark Rachael A.8,Iversen Lars4,Krejsgaard Thorbjørn1ORCID,Bonefeld Charlotte Menné1ORCID,Geisler Carsten1ORCID,Becker Jürgen C.9ORCID,Woetmann Anders1ORCID,Andersen Mads Hald2ORCID,Buus Terkild Brink1ORCID,Ødum Niels1

Affiliation:

1. LEO Foundation Skin Immunology Research Center, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark

2. Center for Cancer Immune Therapy (CCIT), Department of Hematology and Oncology, Copenhagen University Hospital, Herlev Hospital, Herlev, Denmark

3. Department of Physiology and Pharmacology, Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Canada

4. Department of Dermatology, Aarhus University Hospital, Aarhus, Denmark

5. Department of Dermatology, Copenhagen University Hospital, Copenhagen, Denmark

6. Department of Pathology, New York University School of Medicine, New York, USA

7. Department of Pathology, Zealand University Hospital, Roskilde, Denmark

8. Department of Dermatology, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA

9. Translational Skin Cancer Research, German Cancer Consortium (DKTK), University Hospital Essen and Deutsches Krebsforschungszentrum (DKFZ), Essen, Germany

Funder

Novo Nordisk Research Foundation

LEO Foundation

Danish Research Council

Danish Cancer Society

Lundbeck Foundation

LINAK A/S Nordborg

Aage Bangs Foundation

Kraeftfonden

Fight Cancer Program

Publisher

Informa UK Limited

Subject

Oncology,Immunology,Immunology and Allergy

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