Cergutuzumab amunaleukin (CEA-IL2v), a CEA-targeted IL-2 variant-based immunocytokine for combination cancer immunotherapy: Overcoming limitations of aldesleukin and conventional IL-2-based immunocytokines

Author:

Klein Christian1,Waldhauer Inja1,Nicolini Valeria G.1,Freimoser-Grundschober Anne1,Nayak Tapan2,Vugts Danielle J.3,Dunn Claire1,Bolijn Marije3,Benz Jörg2,Stihle Martine2,Lang Sabine1,Roemmele Michaele1,Hofer Thomas1,van Puijenbroek Erwin1,Wittig David1ORCID,Moser Samuel1,Ast Oliver1,Brünker Peter1,Gorr Ingo H.4,Neumann Sebastian2,de Vera Mudry Maria Cristina2ORCID,Hinton Heather1,Crameri Flavio2,Saro Jose1ORCID,Evers Stefan1ORCID,Gerdes Christian1,Bacac Marina1,van Dongen Guus3,Moessner Ekkehard1,Umaña Pablo1

Affiliation:

1. Roche Pharma Research & Early Development, Roche Innovation Center Zurich, Schlieren, Switzerland

2. Roche Pharma Research & Early Development, Roche Innovation Center Basel, Basel, Switzerland

3. Roche Pharma Research & Early Development, Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, the Netherlands

4. Roche Pharma Research & Early Development, Roche Innovation Center Munich, Penzberg, Germany

Publisher

Informa UK Limited

Subject

Oncology,Immunology,Immunology and Allergy

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