Depletion of tumor-associated macrophages switches the epigenetic profile of pancreatic cancer infiltrating T cells and restores their anti-tumor phenotype

Author:

Borgoni Simone12,Iannello Andrea34ORCID,Cutrupi Santina34,Allavena Paola5,D'Incalci Maurizio6,Novelli Francesco1278ORCID,Cappello Paola128ORCID

Affiliation:

1. Dept. of Molecular Biotechnology and Health Sciences, University of Turin, via Nizza 52, Torino, Italy

2. Center for Experimental Research and Medical Studies, University Hospital Città della Salute e della Scienza di Torino, via Santena 5, Torino, Italy

3. Center for Molecular Systems Biology, University of Turin, Orbassano, Turin, Italy

4. Dept. of Clinical and Biological Sciences, University of Turin, Orbassano, Turin, Italy

5. Dept. Immunology and Inflammation, IRCCS-Humanitas Clinical and Research Center, Via Manzoni 56, Rozzano (Milano), Italy

6. Dept. of Oncology, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa 19, Milan, Italy

7. Transplant Immunology Service, University Hospital Città della Salute e della Scienza di Torino, Turin, Italy

8. Molecular Biotechnology Center, via Nizza 52, Torino, Italy

Publisher

Informa UK Limited

Subject

Oncology,Immunology,Immunology and Allergy

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