Interleukin-21 combined with PD-1 or CTLA-4 blockade enhances antitumor immunity in mouse tumor models-Reference-Cited by-同舟云学术

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Interleukin-21 combined with PD-1 or CTLA-4 blockade enhances antitumor immunity in mouse tumor models

Published:2017-10-04 Issue:1 Volume:7 Page:e1377873
ISSN:2162-402X
Container-title:OncoImmunology
language:en
Short-container-title:OncoImmunology

Author:

Lewis Katherine E.¹,Selby Mark J.²,Masters Gregg³,Valle Jose²,Dito Gennaro³,Curtis Wendy R.¹,Garcia Richard¹,Mink Kathy A.¹,Waggie Kimberly S.¹^ORCID,Holdren Matthew S.⁴,Grosso Joseph F.⁵,Korman Alan J.²,Jure-Kunkel Maria³,Dillon Stacey R.¹^ORCID

Affiliation:

1. Oncology Discovery Research, Bristol-Myers Squibb, Seattle, WA

2. Oncology Discovery Research, Bristol-Myers Squibb, Redwood City, CA

3. Oncology Translational Research, Bristol-Myers Squibb, Princeton, NJ

4. Drug Safety Evaluation, Bristol-Myers Squibb, Mt. Vernon, IN

5. Early Clinical Development, Bristol-Myers Squibb, Princeton, NJ

Publisher

Informa UK Limited

Subject

Oncology,Immunology,Immunology and Allergy

Link

https://www.tandfonline.com/doi/pdf/10.1080/2162402X.2017.1377873

Reference47 articles.

1. Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma

2. Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti–CTLA-4 antibodies

3. Preclinical Development of Ipilimumab and Nivolumab Combination Immunotherapy: Mouse Tumor Models, In Vitro Functional Studies, and Cynomolgus Macaque Toxicology

4. Novel Gamma-Chain Cytokines as Candidate Immune Modulators in Immune Therapies for Cancer

5. Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function

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1. Enhanced abscopal anti-tumor response via a triple combination of thermal ablation, IL-21, and PD-1 inhibition therapy;Cancer Immunology, Immunotherapy;2024-06-04

2. Multiomics Analysis of Interleukin-21 as a Potential Immunologic and Biomarker in Hepatocellular Carcinoma;Journal of Immunotherapy;2024-06-04

3. Therapeutic potential of interleukin-21 in cancer;Frontiers in Immunology;2024-04-04

4. Interleukin-21 as an adjuvant in cancer immunotherapy: Current advances and future directions;Biochimica et Biophysica Acta (BBA) - Reviews on Cancer;2024-03

5. Translatability of findings from cynomolgus monkey to human suggests a mechanistic role for IL-21 in promoting immunogenicity to an anti-PD-1/IL-21 mutein fusion protein;Frontiers in Immunology;2024-01-26

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