Critical design parameters to develop biomimetic organ-on-a-chip models for the evaluation of the safety and efficacy of nanoparticles

Author:

Abdelkarim Mahmoud12,Perez-Davalos Luis2,Abdelkader Yasmin23,Abostait Amr2,Labouta Hagar I.1245ORCID

Affiliation:

1. Biomedical Engineering, University of Manitoba, R3T 5V6, Winnipeg, Manitoba, Canada

2. College of Pharmacy, University of Manitoba, R3E 0T5, Winnipeg, Manitoba, Canada

3. Department of Cell Biology, Biotechnology Research Institute, National Research Centre, 12622, Cairo, Egypt

4. Children’s Hospital Research Institute of Manitoba, R3E 3P4, Winnipeg, Manitoba, Canada

5. Faculty of Pharmacy, Alexandria University, 21521, Alexandria, Egypt

Funder

Natural Sciences and Engineering Research Council

New Frontiers Research Fund

Manitoba Medical Service Foundation and University of Manitoba

Publisher

Informa UK Limited

Subject

Pharmaceutical Science

Reference171 articles.

1. (FDA) TUSFaDA. The drug development process: the United States food and drug administration. [Accessed 1 April, 2018]. Available from: https://www.fda.gov/patients/learn-about-drug-and-device-approvals/drug-development-process

2. Diagnosing the decline in pharmaceutical R&D efficiency

3. Breaking Eroom’s Law

4. Estimated Research and Development Investment Needed to Bring a New Medicine to Market, 2009-2018

5. Recommended Guidelines for Developing, Qualifying, and Implementing Complex In Vitro Models (CIVMs) for Drug Discovery

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