1. School of Pharmacy, University of Eastern Finland, Kuopio, Finland
2. School of Medicine, University of Eastern Finland, Kuopio, Finland
3. Division of Pharmacology, Leiden University, Leiden, The Netherlands
4. Finnish Medicines Agency, Assessment of Medicinal Products Department, Pharmacobiological Unit, Kuopio, Finland
5. Department of Anesthesiology and Intensive Care, Kuopio University Hospital, Kuopio, Finland