Design of experiment (DoE) as a quality by design (QbD) tool to optimise formulations of lipid nanoparticles for nose-to-brain drug delivery

Author:

Correia A.C.12ORCID,Moreira J.N.34ORCID,Sousa Lobo J.M.12ORCID,Silva A.C.125ORCID

Affiliation:

1. Faculty of Pharmacy, University of Porto, UCIBIO, REQUIMTE, Porto, Portugal

2. Associate Laboratory i4HB Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, Porto, Portugal

3. CNC - Center for Neuroscience and Cell Biology, Center for Innovative Biomedicine and Biotechnology (CIBB), Faculty of Medicine (Pólo I), University of Coimbra, Coimbra, Portugal

4. Faculty of Pharmacy, Univ Coimbra - University of Coimbra, CIBB, Pólo das Ciências da Saúde, Azinhaga de, Santa Comba, Coimbra, Portugal

5. FP-I3ID (Instituto de Investigação, Inovação e Desenvolvimento), FP-BHS (Biomedical and Health Sciences Research Unit), Faculty of Health Sciences, University Fernando Pessoa, Porto, Portugal

Publisher

Informa UK Limited

Subject

Pharmaceutical Science

Reference101 articles.

1. Design of experiments (DoE) in pharmaceutical development

2. Fisher RA. The design of experiments. the design of experiments. 7th ed. London: Oliver and Boyd; 1960.

3. Design of Experiments in Pharmaceutical Development

4. Agency EM. ICH guideline Q8 (R2) on pharmaceutical development. London: EMA; 2017.

5. Application of Factorial and Response Surface Methodology in Modern Experimental Design and Optimization

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