Regulation of PXR and CAR by protein-protein interaction and signaling crosstalk
Author:
Affiliation:
1. Department of Chemical Biology and Therapeutics, St. Jude Children’s Research Hospital, Memphis, TN, USA
Funder
National Cancer Institute
National Institute of General Medical Sciences
Publisher
Informa UK Limited
Subject
Pharmacology,Toxicology,General Medicine
Link
https://www.tandfonline.com/doi/pdf/10.1080/17425255.2016.1201069
Reference168 articles.
1. The Orphan Human Pregnane X Receptor Mediates the Transcriptional Activation ofCYP3A4by Rifampicin through a Distal Enhancer Module
2. The Nuclear Orphan Receptor CAR-Retinoid X Receptor Heterodimer Activates the Phenobarbital-Responsive Enhancer Module of the CYP2B Gene
3. An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway
4. The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism
5. Nuclear Pregnane X Receptor and Constitutive Androstane Receptor Regulate Overlapping but Distinct Sets of Genes Involved in Xenobiotic Detoxification
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