Pharmacokinetic considerations surrounding the use of levetiracetam for seizure prophylaxis in neurocritical care

Pharmacokinetic considerations surrounding the use of levetiracetam for seizure prophylaxis in neurocritical care – an overview

Published:2022-08-30 Issue:9 Volume:18 Page:575-585
ISSN:1742-5255
Container-title:Expert Opinion on Drug Metabolism & Toxicology
language:en
Short-container-title:Expert Opinion on Drug Metabolism & Toxicology

Author:

D’Onofrio Gianluca¹²,Riva Antonella¹²,Amadori Elisabetta¹²,Lattanzi Simona³^ORCID,Rose Klaus⁴^ORCID,Verrotti Alberto⁵,Striano Pasquale¹²^ORCID

Affiliation:

1. Department of Neurosciences Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (Dinogmi), University of Genoa, Genoa, Italy

2. Pediatric Neurology and Muscular Diseases Unit, IRCCS Istituto “Giannina Gaslini”, Genoa, Italy

3. Department of Experimental and Clinical Medicine, Neurological Clinic, Marche Polytechnic University, Ancona, Italy

4. klausrose Consulting, Riehen, Switzerland

5. Pediatric Unit, Department of Medicine and Surgery, University of Perugia, Perugia, Italy

Publisher

Informa UK Limited

Subject

Pharmacology,Toxicology,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/17425255.2022.2117606

Reference151 articles.

1. Pharmacokinetic profile of levetiracetam

2. U.S. Food and Drug Administration. [Internet]. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/021035s078s080%2C021505s021s024lbl.pdf.

3. Review: New treatment options in status epilepticus: a critical review on intravenous levetiracetam

4. Mechanisms of Levetiracetam in the Control of Status Epilepticus and Epilepsy

5. The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam

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