Combining stem cell-derived hepatocytes with impedance sensing to better predict human drug toxicity
Author:
Affiliation:
1. Department of Medical Oncology, Changzheng Hospital, Navy medical University, Shanghai, China
2. MRC Centre for Regenerative Medicine, 5 Little France Drive, University of Edinburgh, Edinburgh, UK
Funder
Chief Scientist Office
National Natural Science Foundation of China
Royal Society
Publisher
Informa UK Limited
Subject
Pharmacology,Toxicology,General Medicine
Link
https://www.tandfonline.com/doi/pdf/10.1080/17425255.2019.1558208
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1. Highly efficient differentiation of hESCs to functional hepatic endoderm requires ActivinA and Wnt3a signaling
2. SUMOylation of HNF4α regulates protein stability and hepatocyte function
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4. Modelling foetal exposure to maternal smoking using hepatoblasts from pluripotent stem cells
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