Development and evaluation of a physiologically based pharmacokinetic model to predict carvedilol-paroxetine metabolic drug–drug interaction in healthy adults and its extrapolation to virtual chronic heart failure patients for dose optimization-Reference-Cited by-同舟云学术

Development and evaluation of a physiologically based pharmacokinetic model to predict carvedilol-paroxetine metabolic drug–drug interaction in healthy adults and its extrapolation to virtual chronic heart failure patients for dose optimization

Published:2021-05-04 Issue:6 Volume:17 Page:717-724
ISSN:1742-5255
Container-title:Expert Opinion on Drug Metabolism & Toxicology
language:en
Short-container-title:Expert Opinion on Drug Metabolism & Toxicology

Author:

Rasool Muhammad Fawad¹,Läer Stephanie²

Affiliation:

1. Department of Pharmacy Practice, Bahauddin Zakariya University, Multan, Pakistan

2. Department of Clinical Pharmacy and Pharmacotherapy, Heinrich-Heine University, Düsseldorf, Germany

Publisher

Informa UK Limited

Subject

Pharmacology,Toxicology,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/17425255.2021.1921145

Reference33 articles.

1. Dealing with the complex drug-drug interactions: Towards mechanistic models

2. Predictions of Metabolic Drug-Drug Interactions Using Physiologically Based Modelling

3. Clinical implications from drug-drug and drug-disease interactions in older people

4. Physiologically Based Pharmacokinetics Is Impacting Drug Development and Regulatory Decision Making

5. Carvedilol

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