OxLDL-induced macrophage cytotoxicity is mediated by lysosomal rupture and modified by intralysosomal redox-active iron
Author:
Publisher
Informa UK Limited
Subject
General Medicine,Biochemistry
Link
http://www.tandfonline.com/doi/pdf/10.1080/10715769800300431
Reference39 articles.
1. Inactivation of lysosomal proteases by oxidized low density lipoprotein is partially responsible for its poor degradation by mouse peritoneal macrophages.
2. Inactivation of Cathepsin B by Oxidized LDL Involves Complex Formation Induced by Binding of Putative Reactive Sites Exposed at Low pH to Thiols on the Enzyme
3. Oxidized low density lipoprotein is resistant to cathepsins and accumulates within macrophages
4. The intracellular storage and turnover of apolipoprotein B of oxidized LDL in macrophages
5. APOPTOSIS IN HUMAN MONOCYTE-MACROPHAGES EXPOSED TO OXIDIZED LOW DENSITY LIPOPROTEIN
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