Optimizing levodopa therapy, when and how? Perspectives on the importance of delivery and the potential for an early combination approach

Author:

Lees Andrew1,Tolosa Eduardo2,Stocchi Fabrizio3,Ferreira Joaquim J.45ORCID,Rascol Olivier6,Antonini Angelo7,Poewe Werner8

Affiliation:

1. University College London, Reta Lila Weston Institute, London, UK

2. Parkinson disease and Movement Disorders Unit, Neurology Service, Hospital Clinic de Barcelona, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED: CB06/05/0018-ISCIII) Barcelona, Barcelona, Spain

3. Department of Neurology, University San Raffaele and IRCCS San Raffaele Pisana, Rome, Italy

4. Laboratory of Clinical Pharmacology and Therapeutics, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal

5. CNS – Campus Neurológico, Torres Vedras, Portugal

6. Department of Neurosciences and Clinical Pharmacology, Clinical Investigation center CIC1436 and NS-Park/FCRIN network; University Hospital of Toulouse, INSERM and University of Toulouse 3, Toulouse, France

7. Movement Disorders Unit, Study Center for Neurodegenerative Diseases (CESNE), Department of Neuroscience, University of Padova

8. Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria

Funder

No author received any remuneration for the preparation of this article

Publisher

Informa UK Limited

Subject

Pharmacology (medical),Neurology (clinical),General Neuroscience

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