Effectiveness of calcium channel blockade for organophosphorus and carbamate pesticide poisoning – study protocol for an open label, pragmatic, 3-arm RCT repurposing two widely available medicines

Author:

Rabbi Chowdhury Fazle123ORCID,Shaw Suvodip4,Abu Sayeed Abdullah25,Roy Soumitra6,Rahman Abu Shahin Mohammad Mahbubur27,Zafrin Nahida26,Tarafder Pritish8,Rashid Muhammad Halimur9,Ghose Aniruddha25,Chakraborty Shishir Ranjan26,Rahman Muhammad Khalilur7,Rahman Muhammad Sayedur10,Parker Richard11,Ullah Muhammad Mahib212,Hassan Zakir213,Sohag Abdullah Al Mamun214,Amin Muhammad Robed215,Bari Muhammad Shafiqul216,Norrie John11,Faiz M. A.217,Eddleston Michael1819

Affiliation:

1. Department of Internal Medicine, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh

2. CCBOC Trial, Toxicology Society of Bangladesh, Dhaka, Bangladesh

3. Mahidol-Oxford Research Unit (MORU), Bangkok, Thailand

4. Centre for Cardiovascular Science, University of Edinburgh, UK

5. Department of Medicine, Chittagong Medical College Hospital, Chattogram, Bangladesh

6. Department of Medicine, Sylhet MAG Osmani Medical College, Sylhet, Bangladesh

7. Department of Medicine, Rajshahi Medical College Hospital, Rajshahi, Bangladesh

8. Department of Medicine, Khulna Medical College Hospital, Khulna, Bangladesh

9. Department of Medicine, Shaheed Ziaur Rahman Medical College, Bogura, Bangladesh

10. Department of Pharmacology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh

11. Edinburgh Clinical trials Unit, Usher Institute, University of Edinburgh, Edinburgh, UK

12. Toxicology Society of Bangladesh, CCBOC trial, Chattogram, Bangladesh

13. Toxicology Society of Bangladesh, CCBOC trial, Sylhet, Bangladesh

14. Toxicology Society of Bangladesh, CCBOC trial, Bogura, Bangladesh

15. Non-communicable Disease Program, Directorate General of Health Services, Bangladesh

16. Department of Medicine, Dhaka Medical College Hospital, Dhaka, Bangladesh

17. Dev Care Foundation, Dhaka, Bangladesh

18. Pharmacology, Toxicology & Therapeutics, University/BHF Centre for Cardiovascular Science, University of Edinburgh, UK

19. Centre for Pesticide and Suicide Prevention, University of Edinburgh, UK

Funder

ACCORD, University of Edinburgh

MRC JGHT

Publisher

Informa UK Limited

Subject

General Engineering

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