Thymic Presentation of Autoantigens and the Efficiency of Negative Selection

Author:

van den Berg Hugo A.1,Molina-París Carmen12

Affiliation:

1. Mathematics Institute, University of Warwick, Coventry CV4 7AL, UK

2. Department of Applied Mathematics, University of Leeds, Leeds LS2 9JT, UK

Abstract

Antigen recognition by the adaptive cellular immune system is based on a diverse repertoire of antigen receptors. Since this repertoire is formed by genetic recombination, a number of receptors are autoreactive by chance, giving rise to the threat of autoimmune disease. Potentially autoreactive T lymphocytes (T cells) are rendered ineffective by various tolerance mechanisms. One of these mechanisms is negative selection, the deletion from the repertoire of immature autoreactive T cells in the thymus. The present paper shows how to assess the contribution made by negative selection relative to other tolerisation mechanisms by deducing the impact of negative selection on the T cell repertoire from the statistics of autoantigen presentation in the thymus.

Publisher

Hindawi Limited

Subject

General Biochemistry, Genetics and Molecular Biology

Reference81 articles.

1. Akkaraju S., Ho W.Y., Leong D., Canaan K., Davis M.M., Goodnow C.C. A range of CD4 T cell tolerance: partial inactivation to organ-specific antigen allows nondestructive thyroiditis or insulitis 1997; 7: 255-271

2. Anderson A.C., Waldner H., Turchin V., Jabs C., Prabhu Das M., Kuchroo V.K., Nicholson L.B. Autoantigen-responsive T cell clones demonstrate unfocused TCR cross-reactivity toward multiple related ligands: implications for autoimmunity 2000; 202: 88-96

3. Antonia S.J., Geiger T., Miller J., Flavell R.A. Mechanisms of immune tolerance induction through the thymic expression of a peripheral tissue-specific protein 1995; 7: 715-725

4. Ardavín C., Wu L., Li C.-L., Shortman K. Thymic dendritic cells and T cells develop simultaneously in the thymus from a common precursor population 1993; 362: 761-763

5. Arstila T.P., Casrouge A., Baron V., Even J., Kanellopoulos J., Kourilsky P. A direct estimate of the human α-β 1999; 286: 958-961

Cited by 10 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3