A case study where pharmaceutical salts were used to address the issue of low in vivo exposure-Reference-Cited by-同舟云学术

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A case study where pharmaceutical salts were used to address the issue of low in vivo exposure

Published:2018-10-17 Issue:2 Volume:45 Page:202-211
ISSN:0363-9045
Container-title:Drug Development and Industrial Pharmacy
language:en
Short-container-title:Drug Development and Industrial Pharmacy

Author:

Sigfridsson Kalle¹,Ulvinge Marie-Louise²,Svensson Lena³,Granath Anna-Karin⁴

Affiliation:

1. Advanced Drug Delivery, Pharmaceutical Science, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden;

2. Pharmaceutical Technology & Development, AstraZeneca, Gothenburg, Sweden;

3. Cardiovascular and Metabolic Diseases, Bioscience, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden;

4. Global Patient Safety, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden

Publisher

Informa UK Limited

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology

Link

https://www.tandfonline.com/doi/pdf/10.1080/03639045.2018.1529184

Reference39 articles.

1. Pharmaceutical evaluation of early development candidates “the 100 mg-approach”

2. Compound selection for development – Is salt formation the ultimate answer? Experiences with an extended concept of the “100mg approach”

3. Solubility of sparingly-soluble ionizable drugs

4. Salt formation to improve drug solubility

5. Use of pharmaceutical salts and cocrystals to address the issue of poor solubility

Cited by 3 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The curious case of proton migration under pressure in the malonic acid and 4,4′-bipyridine cocrystal;IUCrJ;2024-01-13

2. Salt Screening and Selection;Burger's Medicinal Chemistry and Drug Discovery;2021-04-26

3. A Fully Integrated Assay Panel for Early Drug Metabolism and Pharmacokinetics Profiling;ASSAY and Drug Development Technologies;2020-05-01

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