1. Department of Internal Medicine II,University of Bonn, Bonn, Germany
2. Medical ICU, Department of Internal Medicine I,University of Bonn, Bonn, Germany
3. Toxicological ICU, Department of Clinical Toxicology, Klinikum rechts der Isar, Technical University of Munich,Munich, Germany
4. Medical ICU, Department of Internal Medicine I,University of Bonn, Bonn, Germany; Toxicological ICU,Department of Clinical Toxicology, Klinikum rechts derIsar, Technical University of Munich, Munich, Germany