1. Clinical Pharmacology Department, CHU Nantes, Nantes, France;
2. UMR Inserm 1235 The enteric Nervous System in Gut and Brain Disorders, University of Nantes, France;
3. Intensive Care Unit Department, CHU Nantes, Nantes, France;
4. EA 3826 Thérapeutiques Cliniques et Expérimentales des Infections, University of Nantes, France;
5. Réanimation Chirurgicale Polyvalente, Service d’Anesthésie-Réanimation, hôpital Laënnec, CHU Nantes, Nantes, France