Anti-colchicine Fab fragments prevent lethal colchicine toxicity in a porcine model: a pharmacokinetic and clinical study

Author:

Eddleston Michael12ORCID,Fabresse Nicolas3,Thompson Adrian12,Al Abdulla Ibrahim4,Gregson Rachael2,King Tim2,Astier Alain5,Baud Frederic J.6,Clutton R Eddie2,Alvarez Jean-Claude3

Affiliation:

1. Pharmacology, Toxicology, and Therapeutics, University/BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK;

2. Wellcome Trust Critical Care for Large Animals, Royal (Dick) School of Veterinary Studies and the Roslin Institute, University of Edinburgh, Edinburgh, UK;

3. Laboratoire de Pharmacologie – Toxicologie, Centre Hospitalier Universitaire Raymond Poincaré, AP-HP et MassSpecLab, Plateforme de Spectrométrie de Masse, Inserm U-1173, UFR des Sciences de la Santé Simone Veil, Université Versailles Saint-Quentin, Garches, France;

4. Micropharm Ltd, Newcastle Emlyn, UK;

5. School of Medicine Paris 12, Paris, France;

6. University Paris Diderot, Assistance Publique - Hopitaux de Paris, Paris, France

Publisher

Informa UK Limited

Subject

Toxicology,General Medicine

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