Pulmonary edema after naloxone administration for opioid reversal: a systematic review of case reports and causality assessment using the Naranjo scale

Author:

Joseph Merlyn1ORCID,Amin Khyati2ORCID,Siddens Courtney3,Jaime Gil4,Seeger Christina M.5ORCID,Mercer Kevin6,Chau Terence7ORCID

Affiliation:

1. Department of Pharmacy Practice, Irma Lerma Rangel College of Pharmacy, TX A&M University, Houston, TX, USA

2. Department of Pharmacy, The University of Texas Medical Branch, Galveston, TX, USA

3. Walgreens, Brenham, TX, USA

4. Wal-Mart, Weslaco, TX, USA

5. Sam Houston State University, Huntsville, TX, USA

6. Department of Pharmacy, Houston Methodist West, Houston, TX, USA

7. Department of Pharmacy, Cooper University Hospital, Camden, NJ, USA

Publisher

Informa UK Limited

Reference57 articles.

1. American College of Medical Toxicology and the American Academy of Clinical Toxicology position statement: nalmefene should not replace naloxone as the primary opioid antidote at this time

2. Naloxone induced pulmonary edema

3. Mills CA, Flacke JW, Miller JD, et al. Cardiovascular effects of fentanyl reversal by naloxone at varying arterial carbon dioxide tensions in dogs. Anesth Analg. 1988;67(8):730–736.

4. Clark SB, Soos MP. Noncardiogenic pulmonary edema. StatPearls. Treasure Island (FL) 2024.

5. Pulmonary Complications of Opioid Overdose Treated With Naloxone

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