Modest and variable efficacy of pre-exposure hydroxocobalamin and dicobalt edetate in a porcine model of acute cyanide salt poisoning

Author:

Thompson Adrian1,Dunn Michael2,Jefferson Robert D2,Dissanayake Kosala1,Reed Frances3,Gregson Rachael3,Greenhalgh Stephen3,Clutton R Eddie3,Blain Peter G2,Thomas Simon HL2,Eddleston Michael1ORCID

Affiliation:

1. Department of Pharmacology, Toxicology, & Therapeutics, University/BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK;

2. Medical Toxicology Centre, University of Newcastle, Newcastle upon Tyne, UK;

3. Wellcome Critical Care Laboratory for Large Animals, Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK

Publisher

Informa UK Limited

Subject

Toxicology,General Medicine

Reference45 articles.

1. Acute Chemical Emergencies

2. Cyanide in chemical warfare and terrorism

3. Organisation for the Prohibition of Chemical Weapons. Fact Sheet 4. What is a Chemical Weapon? The Hague, OPCW; 2018. Accessed 24 JUNE 2019. https://www.opcw.org/sites/default/files/documents/publications/fact_sheets/04.pdf.

4. Cyanide: critical issues in diagnosis and treatment

5. Acute Cyanide Toxicity: Mechanisms and Manifestations

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