Importance of mechanistic drug metabolism studies in support of drug discovery: A case study with anN-sulfonylated dipeptide VLA-4 antagonist in rats-Reference-Cited by-同舟云学术

Importance of mechanistic drug metabolism studies in support of drug discovery: A case study with anN-sulfonylated dipeptide VLA-4 antagonist in rats

Published:2008-02 Issue:2 Volume:38 Page:223-237
ISSN:0049-8254
Container-title:Xenobiotica
language:en
Short-container-title:Xenobiotica

Author:

Tang W.,Stearns R. A.,Chen Q.,Bleasby K.,Teffera Y.,Colletti A.,Hafey M.,Evers R.,Dean D. C.,Magriotis P. A.,Lanza T. J.,Lin L. S.,Hagmann W. K.,Baillie T. A.

Publisher

Informa UK Limited

Subject

Health, Toxicology and Mutagenesis,Pharmacology,Toxicology,Biochemistry,General Medicine

Link

http://www.tandfonline.com/doi/pdf/10.1080/00498250701744682

Reference19 articles.

1. Canalicular transport of reduced glutathione in normal and mutant Eisai hyperbilirubinemic rats.

2. The Discovery and Potential of N-Sulfonylated Dipeptide VLA-4 Antagonists

3. The discovery of sulfonylated dipeptides as Potent VLA-4 antagonists

4. Structure of the Integrin VLA-4 and its Cell-Cell and Cell-Matrix Adhesion Functions

5. The Identification and Optimization of Orally Efficacious, Small Molecule VLA-4 Antagonists

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