Reliability of human cryopreserved hepatocytes and liver microsomes asin vitrosystems to predict metabolic clearance
Author:
Publisher
Informa UK Limited
Subject
Health, Toxicology and Mutagenesis,Pharmacology,Toxicology,Biochemistry,General Medicine
Link
http://www.tandfonline.com/doi/pdf/10.1080/00498250802446286
Reference36 articles.
1. THE BINDING OF DRUGS TO HEPATOCYTES AND ITS RELATIONSHIP TO PHYSICOCHEMICAL PROPERTIES
2. Scaling Factors for the Extrapolation of In Vivo Metabolic Drug Clearance From In Vitro Data: Reaching a Consensus on Values of Human Micro-somal Protein and Hepatocellularity Per Gram of Liver
3. Comparison of clearance predictions using primary cultures and suspensions of human hepatocytes
4. Prediction of hepatic clearance using cryopreserved human hepatocytes: a comparison of serum and serum-free incubations
5. Interspecies variation in liver weight, hepatic blood flow, and antipyrine intrinsic clearance: Extrapolation of data to benzodiazepines and phenytoin
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