QTc interval diurnal variations in patients treated with psychotropic medications: implications for the evaluation of drug induced QTc changes

Author:

Cuomo A.1,Libri C.1,Barillà G.1,Cattolico M.1,Carmellini P.1,Fagiolini A.1

Affiliation:

1. School of Medicine, University of Siena, Siena, Italy

Publisher

Informa UK Limited

Subject

Psychiatry and Mental health

Reference19 articles.

1. AN ANALYSIS OF THE TIME-RELATIONS OF ELECTROCARDIOGRAMS.

2. Circadian rhythms and the molecular clock in cardiovascular biology and disease

3. Effects of selective alpha 1-, alpha 2-, beta 1-and beta 2-adrenoceptor stimulation on potentials and contractions in the rabbit heart.

4. European Medicines Agency (2005). The clinical evaluation of QT/QTc Interval prolongation and proarrhythmic potential for non-antiarrhythmic drugs (CHMP/ICH/2/04). https://www.ema.europa.eu/en/documents/scientific-guideline/ich-e-14-clinical-evaluation-qt/qts-interval-prolongation-proarrhythmic-potential-non-antiarrhythmic-drugs-step-5_en.pdf (15 October 2022, date last accessed).

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1. A real-world pharmacovigilance study of drug-induced QT interval prolongation: analysis of spontaneous reports submitted to FAERS;Frontiers in Cardiovascular Medicine;2024-05-13

2. (137) Vortioxetine: A Safe Treatment for Depression in a Medically Complex Patient with QTc Prolongation;Journal of the Academy of Consultation-Liaison Psychiatry;2023-11

3. Vortioxetine;Journal of Clinical Psychopharmacology;2023-08-25

4. Innovations in psychiatry: challenges and future directions;International Review of Psychiatry;2022-11-17

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