The selective NOX4 inhibitor GLX7013159 decreases blood glucose concentrations and human beta-cell apoptotic rates in diabetic NMRI nu/nu mice transplanted with human islets
Author:
Affiliation:
1. Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden
2. Glucox Biotech AB, Stockholm, Sweden
3. Department of Medical Sciences, Uppsala University, Uppsala, Sweden
Funder
Glucox Biotech AB
Swedish Diabetes Foundation
Swedish Research Council
family Ernfors Fund
Barndiabetesfonden
EXODIAB
Stiftelsen Olle Engkvist Byggmästare
Publisher
Informa UK Limited
Subject
General Medicine,Biochemistry
Link
https://www.tandfonline.com/doi/pdf/10.1080/10715762.2023.2284637
Reference48 articles.
1. Heterogeneity of Metabolic Defects in Type 2 Diabetes and Its Relation to Reactive Oxygen Species and Alterations in Beta-Cell Mass
2. Downstream Targets and Intracellular Compartmentalization in Nox Signaling
3. Redox Imbalance in Idiopathic Pulmonary Fibrosis: A Role for Oxidant Cross-Talk Between NADPH Oxidase Enzymes and Mitochondria
4. NOX family NADPH oxidases in liver and in pancreatic islets: a role in the metabolic syndrome and diabetes?
5. Critical role of Nox4-based NADPH oxidase in glucose-induced oxidative stress in the kidney: implications in type 2 diabetic nephropathy
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