Radical-induced purine lesion formation is dependent on DNA helical topology

Author:

Terzidis Michael A.1,Prisecaru Andreea2,Molphy Zara2,Barron Niall2,Randazzo Antonio3,Dumont Elise4,Krokidis Marios G.5,Kellett Andrew2,Chatgilialoglu Chryssostomos15

Affiliation:

1. ISOF, Consiglio Nazionale delle Ricerche, Bologna, Italy;

2. School of Chemical Sciences and National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin, Ireland;

3. Department of Pharmacy, University of Naples “Federico II”, Napoli, Italy;

4. Laboratoire de Chimie, UMR 5182 CNRS, École Normale Supérieure de Lyon, Lyon Cedex, France;

5. NCSR “Demokritos”, Institute of Nanoscience and Nanotechnology, Athens, Greece

Funder

This publication was supported by the Irish Research Council

and is based on the work of COST Action CM1201: Biomimetic Radical Chemistry, supported by COST (European Cooperation in Science and Technology), the Marie Curie Intra-European Fellowship

Italian Association for Cancer Research

GGET/SIEMENS , and the Marie Skłodowska-Curie European Training Network (ITN) ClickGene: Click Chemistry for Future Gene Therapies to Benefit Citizens, Researchers and Industry

Publisher

Informa UK Limited

Subject

General Medicine,Biochemistry

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