Pouchitis

Author:

Schouten W. R.1

Affiliation:

1. Department of Surgery, University Hospital Dijkzigt, Dr. Molewaterplein 40, Rotterdam 3015 GD, The Netherlands

Abstract

Pouchitis is a major long-term complication of the continent ileostomy as well as the ileoanal pouch anastomosis. When diagnosed on the basis of clinical, endoscopic and histologic features, this syndrome has been demonstrated almost exclusively in patients with ulcerative colitis. The clinical course, the endoscopic findings and the histologic abnormalities resemble those of ulcerative colitis. The association with extra-intestinal manifestations further supports the hypothesis that pouchitis represents ulcerative colitis in the small bowel. All ileal reservoirs show bacterial overgrowth, especially of anaerobes. As a response to this altered intraluminal environment chronic inflammation and incomplete colonic metaplasia occur. The efficiency of metronidazole does suggest that bacteriological factors play an important role in the pathogenesis of pouchitis.

Publisher

Hindawi Limited

Subject

Cell Biology,Immunology

Cited by 18 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Pouchitis;Current Opinion in Gastroenterology;2020-01

2. Nephrolithiasis in Patients with Gastrointestinal Disorders;Nutritional and Medical Management of Kidney Stones;2019

3. Etiopathogenesis of Nephrolithiasis in Ulcerative Colitis Patients with the Ileal Pouch Anal Anastomosis;Inflammatory Bowel Diseases;2017-05

4. FK506-Binding Protein 5 mRNA Levels in Ileal Mucosa Are Associated with Pouchitis in Patients with Ulcerative Colitis;Digestive Diseases and Sciences;2015-01-18

5. Inflammatory pouch disease: The spectrum of pouchitis;World Journal of Gastroenterology;2015

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