The expression of Phase II drug-metabolizing enzymes in human B-lymphoblastoid TK6 cells

Author:

Li Xilin1,Li Yuxi2,Ning Kylie G.13,Chen Si2ORCID,Guo Lei2ORCID,Bonzo Jessica A.4ORCID,Mei Nan1ORCID

Affiliation:

1. Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, USA

2. Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, USA

3. Krieger School of Arts and Sciences, Johns Hopkins University, Baltimore, MD, USA

4. Division of Pharmacology/Toxicology for Immunology and Inflammation, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA

Funder

National Center for Toxicological Research

Publisher

Informa UK Limited

Subject

Health, Toxicology and Mutagenesis,Cancer Research

Reference35 articles.

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2. OECD. In vitro mammalian cell gene mutation tests using the thymidine kinase gene, OECD guideline for testing of chemicals, No. 490. 2015. http://www.oecd-ilibrary.org/environment/test-no-490-in-vitro-mammalian-cell-gene-mutation-tests-using-the-thymidine-kinase-gene_9789264242241-en. (Accessed 19 February 2022).

3. The enzyme-modified comet assay: Past, present and future

4. Standardized cell sources and recommendations for good cell culture practices in genotoxicity testing

5. Relationships between p53 status, apoptosis and induction of micronuclei in different human and mouse cell lines in vitro: Implications for improving existing assays

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