Dysfunctional Bronchial Cilia Are a Feature of Chronic Obstructive Pulmonary Disease (COPD)

Author:

Thomas Biju12,Koh Mariko Siyue23ORCID,O’Callaghan Christopher4,Allen John Carson5ORCID,Rutman Andrew6,Hirst Robert Anthony6,Connolly John7ORCID,Low Su Ying3,Thun How Ong3,Chian Min Loo3,Lim Wan Teck278,Lin Ean Oon Lynette29ORCID,He Qixian1,Teoh Oon Hoe12,Lapperre Therese Sophie231011ORCID

Affiliation:

1. Department of Respiratory Medicine, KK Women’s and Children’s Hospital, Singapore, Singapore

2. Duke-NUS Medical School, Singapore, Singapore

3. Department of Respiratory and Critical Care Medicine, Singapore General Hospital, Singapore, Singapore

4. Respiratory, Critical Care and Anaesthesia, UCL Great Ormond Street Institute of Child Health, University College London, London, United Kingdom

5. Department of Quantitative Medicine, Duke-NUS Medical School, Singapore, Singapore

6. Department of Respiratory Sciences, University of Leicester, Leicester, United Kingdom

7. A*STAR, Institute of Molecular and Cell Biology, Singapore, Singapore

8. Singhealth Investigational Medicine Unit, Singapore General Hospital, Singapore, Singapore

9. Department of Molecular Pathology, Singapore General Hospital, Singapore, Singapore

10. Department of Pulmonology, University Hospital Antwerp, Antwerp, Belgium

11. Laboratory of Experimental Medicine and Paediatrics, Faculty of Medicine & Health Sciences, University of Antwerp, Antwerp, Belgium

Funder

National Medical Research Council

NIHR GOSH BRC

Publisher

Informa UK Limited

Subject

Pulmonary and Respiratory Medicine

Reference42 articles.

1. Global initiative for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. 2021. https://goldcopd.org

2. Susceptibility to Exacerbation in Chronic Obstructive Pulmonary Disease

3. Acute COPD Exacerbations

4. Relationship between bacterial colonisation and the frequency, character, and severity of COPD exacerbations

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