Caspase inhibitors for the treatment of liver disease: friend or foe?
Author:
Affiliation:
1. Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS, USA
Funder
National Institute of General Medical Sciences
National Institute of Environmental Health Sciences
National Institutes of Health
Publisher
Informa UK Limited
Subject
Gastroenterology,Hepatology
Link
https://www.tandfonline.com/doi/pdf/10.1080/17474124.2017.1300060
Reference24 articles.
1. Apoptosis and necrosis in liver disease
2. Mitochondria and cell death: outer membrane permeabilization and beyond
3. A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD
4. Systemic injection of a tripeptide inhibits the intracellular activation of CPP32-like proteases in vivo and fully protects mice against Fas-mediated fulminant liver destruction and death.
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