1. a Laboratory of Environmental Biology, Hokkaido University School of Medicine, Kita 15, Nishi 7, Kita-ku, Sapporo 060-8638, Japan
2. b Centre for Research and Development in Higher Education, Hokkaido University, Sapporo 060-0817, Japan
3. c Department of Environmental Medicine and Informatics, Graduate School of Environmental Earth Science, Hokkaido University, Sapporo 060-0810, Japan