The Effect of High Fat-Induced Obesity on Cardiovascular and Physical Activity and Opioid Responsiveness in Conscious Rats
Author:
Publisher
Informa UK Limited
Subject
General Medicine,Physiology,Internal Medicine
Link
http://www.tandfonline.com/doi/pdf/10.1080/10641960500468326
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1. Regional haemodynamic effects of μ-, δ-, and κ-opioid agonists microinjected into the hypothalamic paraventricular nuclei of conscious, unrestrained rats
2. High fat feeding is associated with increased blood pressure, sympathetic nerve activity and hypothalamic mu opioid receptors
3. Endomorphin-1 and endomorphin-2, endogenous ligands for the μ-opioid receptor, inhibit electrical activity of rat rostral ventrolateral medulla neurons in vitro
4. Leptin-induced increase in sympathetic nervous and cardiovascular tone is mediated by proopiomelanocortin (POMC) products
5. Chronic intracerebroventricular insulin attenuates the leptin-mediated but not alpha melanocyte stimulating hormone increase in sympathetic and cardiovascular responses
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