Effects of ibrutinib on in vitro platelet aggregation in blood samples from healthy donors and donors with platelet dysfunction

Author:

Ninomoto Joi1,Mokatrin Ahmad1,Kinoshita Taisei1ORCID,Marimpietri Carol1,Barrett Terrance D.2,Chang Betty Y.1,Sukbuntherng Juthamas1,James Danelle F.1,Crowther Mark3

Affiliation:

1. Pharmacyclics LLC, an AbbVie Company, Sunnyvale, CA, USA

2. Janssen Research & Development LLC, San Diego, CA, USA

3. Department of Medicine, McMaster University, Hamilton, Canada

Publisher

Informa UK Limited

Subject

Hematology,Hematology

Reference26 articles.

1. The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy

2. IMBRUVICA® (ibrutinib) capsules, for oral use. IMBRUVICA® (ibrutinib) tablets, for oral use [prescribing information]. Sunnyvale (CA): Pharmacyclics LLC; November 2019.

3. European Medicines Agency. Imbruvica: EPAR – product information. 2018. [cited 6 Feb 2018]. Available from: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/003791/WC500177775.pdf

4. Tec regulates platelet activation by GPVI in the absence of Btk

5. Bruton's Tyrosine Kinase mediates platelet receptor-induced generation of microparticles: A potential mechanism for amplification of inflammatory responses in rheumatoid arthritis synovial joints

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