Bacterial and metabolic phenotypes associated with inadequate response to ursodeoxycholic acid treatment in primary biliary cholangitis

Author:

Martinez-Gili Laura12ORCID,Pechlivanis Alexandros13ORCID,McDonald Julie A.K.2ORCID,Begum Sofina2ORCID,Badrock Jonathan4,Dyson Jessica K.56ORCID,Jones Rebecca7,Hirschfield Gideon8ORCID,Ryder Stephen D.9ORCID,Sandford Richard4,Rushbrook Simon10,Thorburn Douglas11,Taylor-Robinson Simon D.12ORCID,Crossey Mary M.E.2,Marchesi Julian R.2ORCID,Mells George413,Holmes Elaine214ORCID,Jones David56

Affiliation:

1. Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK

2. Division of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK

3. Biomic_Auth, Bioanalysis and Omics Laboratory, Center for Interdisciplinary Research and Innovation (CIRI-AUTH), Balkan Centre, Thessaloniki, Greece

4. Academic Department of Medical Genetics, Cambridge University, Cambridge, UK

5. Liver Unit, Freeman Hospital, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK

6. Institute of Translational and Clinical Research, Newcastle University, Newcastle upon Tyne, UK

7. Leeds Liver Unit, St James’s University Hospital, Leeds, UK

8. Center for Liver and Gastroenterology Research and National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre, University of Birmingham, Birmingham, UK

9. NIHR Biomedical Research Centre at Nottingham University Hospitals NHS Trust, University of Nottingham, Nottingham, UK

10. Department of Gastroenterology, Norfolk and Norwich University Hospital, Norwich, UK

11. UCL Royal Free Campus, Royal Free Hospital, University College London Institute of Liver and Digestive Health, London, UK

12. Department of Electrical and Electronic Engineering, Imperial College London, London, UK

13. Department of Hepatology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK

14. Center for Computational & Systems Medicine, Murdoch University, Perth, Australia

Funder

Medical Research Council

Publisher

Informa UK Limited

Subject

Infectious Diseases,Microbiology (medical),Gastroenterology,Microbiology

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