Sialic acid-based probiotic intervention in lactating mothers improves the neonatal gut microbiota and immune responses by regulating sialylated milk oligosaccharide synthesis via the gut

Sialic acid-based probiotic intervention in lactating mothers improves the neonatal gut microbiota and immune responses by regulating sialylated milk oligosaccharide synthesis via the gut–breast axis

Published:2024-04-17 Issue:1 Volume:16 Page:
ISSN:1949-0976
Container-title:Gut Microbes
language:en
Short-container-title:Gut Microbes

Author:

Wang Yushuang¹²,Rui Binqi¹,Ze Xiaolei³,Liu Yujia¹,Yu Da⁴,Liu Yinhui¹,Li Zhi²,Xi Yu³,Ning Xixi¹,Lei Zengjie¹,Yuan Jieli¹,Li Liang³,Zhang Xuguang³,Li Wenzhe⁵,Deng Yanjie⁴,Yan Jingyu⁶,Li Ming¹^ORCID

Affiliation:

1. Department of Microecology, College of Basic Medical Science, Dalian Medical University, Dalian, China

2. Department of Clinical Laboratory, Central Hospital of Dalian University of Technology, Dalian, China

3. Microbiome Research and Application Center, BYHEALTH Institute of Nutrition & Health, Guangzhou, China

4. The Third Ward of Obstetrics and Gynecology at Chunliu District, Dalian Women and Children Medical Center (Group), Dalian, China

5. Guangdong Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology, Shantou University Medical College, Shantou, China

6. Dalian Institute of Chemical Physics, Chinese Academy of Sciences Key Laboratory of Separation Science for Analytical Chemistry, Dalian, China

Funder

the National Natural Science Foundation of China

he Nature Science Foundation of Liaoning Province, China

the BYHEALTH Nutrition and Health Research Foundation under Grant

Publisher

Informa UK Limited

Link

https://www.tandfonline.com/doi/pdf/10.1080/19490976.2024.2334967

Reference57 articles.

1. Selective maternal seeding and environment shape the human gut microbiome

2. Neonatal diet alters fecal microbiota and metabolome profiles at different ages in infants fed breast milk or formula

3. Studies and Application of Sialylated Milk Components on Regulating Neonatal Gut Microbiota and Health

4. Sialylated Oligosaccharides and Glycoconjugates of Human Milk. The Impact on Infant and Newborn Protection, Development and Well-Being

5. Mechanisms by which sialylated milk oligosaccharides impact bone biology in a gnotobiotic mouse model of infant undernutrition