Chemotherapy-induced microbiota exacerbates the toxicity of chemotherapy through the suppression of interleukin-10 from macrophages

Author:

He Zhen1234,Xie Hongyu5634,Xu Haoyang12,Wu Jinjie12634,Zeng Wanyi7,He Qilang7,Jobin Christian89,Jin Sanqing53,Lan Ping12634

Affiliation:

1. Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China

2. Department of Colorectal Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China

3. Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China

4. Key Laboratory of Human Microbiome and Chronic Diseases, Sun Yat-sen University, Ministry of Education, Guangzhou, Guangdong, China

5. Department of Anesthesia, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China

6. Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China

7. School of Medicine, Shenzhen Campus of Sun Yat-sen University, Shenzhen, Guangzhou, China

8. Department of Medicine, Division of Gastroenterology, University of Florida, Florida, USA

9. Department of Infectious Diseases and Pathology, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA

Funder

National Key R&D Program of China

Guangdong Provincial Clinical Research Center for Digestive Diseases

National Key Clinical Discipline; National Natural Science Foundation of China

Science and Technology Program of Shenzhen, China

Natural Science Foundation of Guangdong Province, China

Science and Technology Program of Guangdong Province, China

Guang Dong Cheung Kong Philanthropy Foundation

Publisher

Informa UK Limited

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