Prevotella copri exhausts intrinsic indole-3-pyruvic acid in the host to promote breast cancer progression: inactivation of AMPK via UHRF1-mediated negative regulation

Author:

Su Jiyan12,Lin Xiaojie3,Li Dan45,Yang Chunmin3,Lv Shumei4,Chen Xiaohong46,Yang Xiujuan12,Pan Botao12,Xu Rui3,Ren Liping3,Zhang Yanfang3,Xie Yizhen47,Chen Qianjun38,Xia Chenglai12

Affiliation:

1. Scientific Research Center, Foshan Maternity & Child Healthcare Hospital, Foshan, P. R. China

2. School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, P. R. China

3. Breast Department, Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China

4. Institute of Microbiology, Guangdong Academy of Sciences, State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Safety and Health, Key Laboratory of Agricultural Microbiomics and Precision Application, Ministry of Agriculture and Rural Affairs, Guangzhou, P. R. China

5. Department of Pharmacy, Guangdong Second Provincial General Hospital, Guangzhou, P. R. China

6. Department of Basic Medical Science, Xiamen Medical College, Xiamen, P. R. China

7. R&D Department, Guangdong Yuewei Edible Fungi Technology Co. Ltd, Guangzhou, P. R. China

8. State Key Laboratory of Traditional Chinese Medicine Syndrome, Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, P. R. China

Funder

National Natural Science Foundation of China

Natural Science Foundation of Guangdong

Guangdong Basic and Applied Basic Research Foundation

Natural Science Foundation of Fujian Province

Talent Training Project Fund of Guangzhou University of Traditional Chinese Medicine grant

Science and Technology Bureau of Foshan

Foshan Medicine Dengfeng Project of China

Publisher

Informa UK Limited

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